Pope Leo XIV called Wednesday for humanitarian aid to reach the Gaza Strip and for an end to the “heartbreaking” toll on its people, as he presided over his first general audience in St. Peter’s Square.

The Vatican said that around 40,000 people were on hand for the audience, which came just days after an estimated 200,000 people attended the inaugural Mass on Sunday for history’s first American pope.

Leo, the former Cardinal Robert Prevost of Chicago, began the audience with a tour through the piazza in the popemobile and stopped to bless several babies. In addressing specific greetings to different groups of pilgrims, Leo spoke in his native English, his fluent Spanish as well as the traditional Italian of the papacy.